Therapeutic potential of ADAM10 modulation in Alzheimer’s disease: a review of the current evidence
Abstract Alzheimer’s disease (AD), the most common neurodegenerative disease worldwide, is caused by loss of neurons and synapses in central nervous system. Several causes for neuronal death in AD have been introduced, the most important of which are extracellular amyloid β (Aβ) accumulation and agg...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01072-w |
| _version_ | 1797864007551418368 |
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| author | Mohammad Rafi Khezri Mehdi Mohebalizadeh Morteza Ghasemnejad-Berenji |
| author_facet | Mohammad Rafi Khezri Mehdi Mohebalizadeh Morteza Ghasemnejad-Berenji |
| author_sort | Mohammad Rafi Khezri |
| collection | DOAJ |
| description | Abstract Alzheimer’s disease (AD), the most common neurodegenerative disease worldwide, is caused by loss of neurons and synapses in central nervous system. Several causes for neuronal death in AD have been introduced, the most important of which are extracellular amyloid β (Aβ) accumulation and aggregated tau proteins. Increasing evidence suggest that targeting the process of Aβ production to reduce its deposition can serve as a therapeutic option for AD management. In this regard, therapeutic interventions shown that a disintegrin and metalloproteinase domain-containing protein (ADAM) 10, involved in non-amyloidogenic pathway of amyloid precursor protein processing, is known to be a suitable candidate. Therefore, this review aims to examine the molecular properties of ADAM10, its role in AD, and introduce it as a therapeutic target to reduce the progression of the disease. Video abstract |
| first_indexed | 2024-04-09T22:45:43Z |
| format | Article |
| id | doaj.art-4096e41939644d929fead58e717a4b1a |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-04-09T22:45:43Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-4096e41939644d929fead58e717a4b1a2023-03-22T11:53:11ZengBMCCell Communication and Signaling1478-811X2023-03-0121111210.1186/s12964-023-01072-wTherapeutic potential of ADAM10 modulation in Alzheimer’s disease: a review of the current evidenceMohammad Rafi Khezri0Mehdi Mohebalizadeh1Morteza Ghasemnejad-Berenji2Student Research Committee, Urmia University of Medical SciencesStudent Research Committee, Urmia University of Medical SciencesStudent Research Committee, Urmia University of Medical SciencesAbstract Alzheimer’s disease (AD), the most common neurodegenerative disease worldwide, is caused by loss of neurons and synapses in central nervous system. Several causes for neuronal death in AD have been introduced, the most important of which are extracellular amyloid β (Aβ) accumulation and aggregated tau proteins. Increasing evidence suggest that targeting the process of Aβ production to reduce its deposition can serve as a therapeutic option for AD management. In this regard, therapeutic interventions shown that a disintegrin and metalloproteinase domain-containing protein (ADAM) 10, involved in non-amyloidogenic pathway of amyloid precursor protein processing, is known to be a suitable candidate. Therefore, this review aims to examine the molecular properties of ADAM10, its role in AD, and introduce it as a therapeutic target to reduce the progression of the disease. Video abstracthttps://doi.org/10.1186/s12964-023-01072-wADAM10Alzheimer’s diseaseAmyloid βNatural compounds |
| spellingShingle | Mohammad Rafi Khezri Mehdi Mohebalizadeh Morteza Ghasemnejad-Berenji Therapeutic potential of ADAM10 modulation in Alzheimer’s disease: a review of the current evidence Cell Communication and Signaling ADAM10 Alzheimer’s disease Amyloid β Natural compounds |
| title | Therapeutic potential of ADAM10 modulation in Alzheimer’s disease: a review of the current evidence |
| title_full | Therapeutic potential of ADAM10 modulation in Alzheimer’s disease: a review of the current evidence |
| title_fullStr | Therapeutic potential of ADAM10 modulation in Alzheimer’s disease: a review of the current evidence |
| title_full_unstemmed | Therapeutic potential of ADAM10 modulation in Alzheimer’s disease: a review of the current evidence |
| title_short | Therapeutic potential of ADAM10 modulation in Alzheimer’s disease: a review of the current evidence |
| title_sort | therapeutic potential of adam10 modulation in alzheimer s disease a review of the current evidence |
| topic | ADAM10 Alzheimer’s disease Amyloid β Natural compounds |
| url | https://doi.org/10.1186/s12964-023-01072-w |
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