The shape of the lymphocyte receptor repertoire: lessons from the B cell receptor

The shape of the lymphocyte receptor repertoire: lessons from the B cell receptor

Both the B cell receptor (BCR) and the T cell receptor (TCR) repertoires are generated through essentially identical processes of V(D)J recombination, exonuclease trimming of germline genes and the random addition of non-template encoded nucleotides. The naïve TCR repertoire is constrained...

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Bibliographic Details
Main Authors: Katherine J. L. Jackson, Marie J. Kidd, Yan eWang, Andrew M Collins
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Immunology
Subjects:
V(D)J Recombination
TCR repertoire
BCR repertoire
public clonotypes
private clonotypes
combinatorial diversity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00263/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00263/full

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