Human Cancer Cells Sense Cytosolic Nucleic Acids Through the RIG-I–MAVS Pathway and cGAS–STING Pathway

Human Cancer Cells Sense Cytosolic Nucleic Acids Through the RIG-I–MAVS Pathway and cGAS–STING Pathway

Pattern recognition receptors (PRRs) are germline-encoded host sensors of the innate immune system. Some human cancer cells have been reported to express PRRs. However, nucleic acid sensors in human cancers have not been studied in detail. Therefore, we systematically analyzed the expression, molecu...

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Bibliographic Details
Main Authors: Yuan Qiao, Shan Zhu, Shuanglin Deng, Shan-Shan Zou, Bao Gao, Guoxia Zang, Jing Wu, Yuxue Jiang, Yong-Jun Liu, Jingtao Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cancer cell
nucleic acid
RIG-I
STING
IFN-β
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.606001/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.606001/full

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