Decreased methylation in the SNAI2 and ADAM23 genes associated with de-differentiation and haematogenous dissemination in breast cancers

Decreased methylation in the SNAI2 and ADAM23 genes associated with de-differentiation and haematogenous dissemination in breast cancers

Abstract Background In breast cancer (BC), deregulation of DNA methylation leads to aberrant expressions and functions of key regulatory genes. In our study, we investigated the relationship between the methylation profiles of genes associated with cancer invasivity and clinico-pathological paramete...

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Bibliographic Details
Main Authors: Lenka Kalinkova, Iveta Zmetakova, Bozena Smolkova, Gabriel Minarik, Tatiana Sedlackova, Viera Horvathova Kajabova, Zuzana Cierna, Michal Mego, Ivana Fridrichova
Format: Article
Language:English
Published: BMC 2018-09-01
Series:BMC Cancer
Subjects:
SNAI2 methylation
ADAM23 methylation
Breast cancer
Cancer cell de-differentiation
Haematogenous dissemination
Online Access:http://link.springer.com/article/10.1186/s12885-018-4783-x

Internet

http://link.springer.com/article/10.1186/s12885-018-4783-x

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