Myeloid hypoxia-inducible factor HIF1A provides cardio-protection during ischemia and reperfusion via induction of netrin-1

Myeloid hypoxia-inducible factor HIF1A provides cardio-protection during ischemia and reperfusion via induction of netrin-1

The transcription factor hypoxia-inducible factor HIF1A induces cardioprotection from ischemia and reperfusion injury. Here, we investigate tissue-specific pathways that are critical for HIF1A-elicited tissue protection. Initial studies showed that mice with induced global Hif1a deletion (Hif1aloxP/...

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Bibliographic Details
Main Authors: Ka Lin Heck-Swain, Jiwen Li, Wei Ruan, Xiaoyi Yuan, Yanyu Wang, Michael Koeppen, Holger K. Eltzschig
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
hypoxia
myocardial infarction
polymorphonuclear neutrophil (PMN)
reperfusion
heart
hypoxia inducible factor (HIF)
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.970415/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.970415/full

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