人脐血间充质干细胞激活磷脂酰肌醇3激酶/蛋白激酶B通路对脑缺血再灌注大鼠的神经保护作用 The Neuroprotective Effects of Human Umbilical Cord Blood Mesenchymal Stem Cells on Cerebral Ischemia-Reperfusion Rats by Activating PI3K/Akt Pathway
目的 探究人脐血间充质干细胞（human umbilical cord blood mesenchymal stem cells，hUCBMSCs）调控磷脂酰肌醇3激酶/蛋白激酶B（phosphoinositide3-kinase/protein kinase B，PI3K/Akt）通路对脑缺血再灌注损伤大鼠周细胞表达和神经功能变化的影响。 方法 取雄性SD大鼠共72只，随机分组为假手术组、模型组、干细胞组、干细胞+抑制剂组，每组18只。除假手术组外，剩余各组均建立脑缺血再灌注模型。造模成功后，模型组尾静脉注射0.1 mL的磷酸盐缓冲盐溶液（phosphate-buffered saline...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Chinese Journal of Stroke
2023-11-01
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| Series: | Zhongguo cuzhong zazhi |
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| Online Access: | http://www.chinastroke.org.cn/CN/article/openArticlePDF.jsp?id=3922 |