Synthesis and Antiproliferative Effect of Halogenated Coumarin Derivatives

Synthesis and Antiproliferative Effect of Halogenated Coumarin Derivatives

A series of 6- and 6,8-halocoumarin derivatives have been investigated as potential antiproliferative compounds against a panel of tumor and normal cell lines. Cytotoxic effects were determined by the MTT method. To investigate the potential molecular mechanism involved in the cytotoxic effect, apop...

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Bibliographic Details
Main Authors: Tinuccia Dettori, Giuseppina Sanna, Andrea Cocco, Gabriele Serreli, Monica Deiana, Vanessa Palmas, Valentina Onnis, Luca Pilia, Nicola Melis, Davide Moi, Paola Caria, Francesco Secci
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
coumarins
antiproliferative activity
TPC-1 cells
apoptosis
ROS
Online Access:https://www.mdpi.com/1420-3049/27/24/8897

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https://www.mdpi.com/1420-3049/27/24/8897

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