Small-molecule compound SYG-180-2-2 attenuates Staphylococcus aureus virulence by inhibiting hemolysin and staphyloxanthin production

Small-molecule compound SYG-180-2-2 attenuates Staphylococcus aureus virulence by inhibiting hemolysin and staphyloxanthin production

Multi-drug resistant Staphylococcus aureus infection is still a serious threat to global health. Therefore, there is an urgent need to develop new antibacterial agents based on virulence factor therapy to overcome drug resistance. Previously, we synthesized SYG-180-2-2 (C21H16N2OSe), an effective sm...

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Bibliographic Details
Main Authors: Lulin Rao, Yanlei Xu, Li Shen, Xinyi Wang, Huilin Zhao, Bingjie Wang, Jiao Zhang, Yanghua Xiao, Yinjuan Guo, Yaoguang Sheng, Lixia Cheng, Zengqiang Song, Fangyou Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Staphylococcus aureus
SYG-180-2-2
virulence
hemolysin
staphyloxanthin
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.1008289/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2022.1008289/full

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