Are standing osmotic gradients the main driver of cerebrospinal fluid production? A computational analysis

Abstract Background The mechanisms of cerebrospinal fluid (CSF) production by the ventricular choroid plexus (ChP) have not been fully deciphered. One prominent hypothesized mechanism is trans-epithelial water transport mediated by accumulation of solutes at the luminal ChP membrane that produces lo...

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Bibliographic Details
Main Authors: Pooya Razzaghi Khamesi, Vasileios Charitatos, Eva K. Heerfordt, Nanna MacAulay, Vartan Kurtcuoglu
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Fluids and Barriers of the CNS
Subjects:
Online Access:https://doi.org/10.1186/s12987-023-00419-2