Mechanics-driven nuclear localization of YAP can be reversed by N-cadherin ligation in mesenchymal stem cells

Mechanics-driven nuclear localization of YAP can be reversed by N-cadherin ligation in mesenchymal stem cells

Mesenchymal stem cells adopt differentiation pathways based upon mechanical cues in their environment which change throughout development. Here the authors develop a material and culture system to modify and measure the degree to which cells retain cumulative effects of mechanosensing to explore how...

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Bibliographic Details
Main Authors: Cheng Zhang, Hongyuan Zhu, Xinru Ren, Bin Gao, Bo Cheng, Shaobao Liu, Baoyong Sha, Zhaoqing Li, Zheng Zhang, Yi Lv, Haohua Wang, Hui Guo, Tian Jian Lu, Feng Xu, Guy M. Genin, Min Lin
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26454-x

Internet

https://doi.org/10.1038/s41467-021-26454-x

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