Structure and flexibility of the yeast NuA4 histone acetyltransferase complex

Structure and flexibility of the yeast NuA4 histone acetyltransferase complex

The NuA4 protein complex acetylates histones H4 and H2A to activate both transcription and DNA repair. We report the 3.1-Å resolution cryo-electron microscopy structure of the central hub of NuA4, which flexibly tethers the histone acetyltransferase (HAT) and Trimer Independent of NuA4 involved in T...

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Bibliographic Details
Main Authors: Stefan A Zukin, Matthew R Marunde, Irina K Popova, Katarzyna M Soczek, Eva Nogales, Avinash B Patel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-10-01
Series:eLife
Subjects:
gene expression
histone acetylation
histone modifications
cryo-EM
Online Access:https://elifesciences.org/articles/81400

Internet

https://elifesciences.org/articles/81400

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