Combining Albumin-Binding Properties and Interaction with Pemetrexed to Improve the Tissue Distribution of Radiofolates

Combining Albumin-Binding Properties and Interaction with Pemetrexed to Improve the Tissue Distribution of Radiofolates

Folic-acid-based radioconjugates have been developed for nuclear imaging of folate receptor (FR)-positive tumors; however, high renal uptake was unfavorable in view of a therapeutic application. Previously, it was shown that pre-injection of pemetrexed (PMX) increased the tumor-to-kidney ratio of ra...

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Bibliographic Details
Main Authors: Cristina Müller, Patrycja Guzik, Klaudia Siwowska, Susan Cohrs, Raffaella M. Schmid, Roger Schibli
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molecules
Subjects:
pemetrexed
folic acid
radiofolate
albumin-binder
SPECT
177Lu
KB
IGROV-1
Online Access:http://www.mdpi.com/1420-3049/23/6/1465

Internet

http://www.mdpi.com/1420-3049/23/6/1465

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