APOE genotype-specific methylation patterns are linked to Alzheimer disease pathology and estrogen response

APOE genotype-specific methylation patterns are linked to Alzheimer disease pathology and estrogen response

Abstract The joint effects of APOE genotype and DNA methylation on Alzheimer disease (AD) risk is relatively unknown. We conducted genome-wide methylation analyses using 2,021 samples in blood (91 AD cases, 329 mild cognitive impairment, 1,391 controls) and 697 samples in brain (417 AD cases, 280 co...

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Bibliographic Details
Main Authors: Rebecca Panitch, Nathan Sahelijo, Junming Hu, Kwangsik Nho, David A. Bennett, Kathryn L. Lunetta, Rhoda Au, Thor D. Stein, Lindsay A. Farrer, Gyungah R. Jun
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-024-02834-x

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https://doi.org/10.1038/s41398-024-02834-x

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