Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole–Indole Conjugates as Anticancer CDK Inhibitors

Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole–Indole Conjugates as Anticancer CDK Inhibitors

On account of their overexpression in a wide range of human malignancies, cyclin-dependent kinases (CDKs) are among the most validated cancer targets, and their inhibition has been featured as a valuable strategy for anticancer drug discovery. In this study, a hybrid pharmacophore approach was adopt...

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Bibliographic Details
Main Authors: Tarfah Al-Warhi, Ahmed M. El Kerdawy, Nada Aljaeed, Omnia E. Ismael, Rezk R. Ayyad, Wagdy M. Eldehna, Hatem A. Abdel-Aziz, Ghada H. Al-Ansary
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
anti-proliferative activity
apoptosis
breast cancer
oxindole
CDK4 inhibitors
Online Access:https://www.mdpi.com/1420-3049/25/9/2031

Internet

https://www.mdpi.com/1420-3049/25/9/2031

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