Use of Clinical Isolates to Establish Criteria for a Mouse Model of Latent Cryptococcus neoformans Infection

Use of Clinical Isolates to Establish Criteria for a Mouse Model of Latent Cryptococcus neoformans Infection

The mechanisms of latency in the context of C. neoformans infection remain poorly understood. Two reasons for this gap in knowledge are: 1) the lack of standardized criteria for defining latent cryptococcosis in animal models and 2) limited genetic and immunological tools available for studying host...

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Bibliographic Details
Main Authors: Minna Ding, Kyle D. Smith, Darin L. Wiesner, Judith N. Nielsen, Katrina M. Jackson, Kirsten Nielsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Cryptococcus neoformans
cryptococcosis
cryptococcal meningitis
latent fungal infections
pulmonary granulomas
adaptive immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.804059/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.804059/full

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