A network paradigm predicts drug synergistic effects using downstream protein–protein interactions
Abstract In some cases, drug combinations affect adverse outcome phenotypes by binding the same protein; however, drug‐binding proteins are associated through protein–protein interaction (PPI) networks within the cell, suggesting that drug phenotypes may result from long‐range network effects. We fi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-11-01
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| Series: | CPT: Pharmacometrics & Systems Pharmacology |
| Online Access: | https://doi.org/10.1002/psp4.12861 |