Tobramycin-loaded nanoparticles of thiolated chitosan for ocular drug delivery: Preparation, mucoadhesion and pharmacokinetic evaluation

Tobramycin-loaded nanoparticles of thiolated chitosan for ocular drug delivery: Preparation, mucoadhesion and pharmacokinetic evaluation

The present work aimed to develop nanoparticles of tobramycin (TRM) using thiolated chitosan (TCS) in order to improve the mucoadhesion, antibacterial effect and pharmacokinetics. The nanoparticles were evaluated for their compatibility, thermal stability, particle size, zeta potential, mucoadhesion...

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Bibliographic Details
Main Authors: Sadaf Javed, Ghulam Abbas, Shahid Shah, Akhtar Rasul, Muhammad Irfan, Ammara Saleem, Khaled M. Hosny, Sahar M. Bukhary, Awaji Y. Safhi, Fahad Y. Sabei, Mohammed A. Majrashi, Hala M. Alkhalidi, Mohammed Alissa, Sajid Mehmood Khan, Muhammad Hanif
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Heliyon
Subjects:
Thiolated chitosan
nanoparticles
Mucoadhesion
Ocular irritation test
Antimicrobial activity
Pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023070858

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http://www.sciencedirect.com/science/article/pii/S2405844023070858

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