Targeted up-regulation of Drp1 in dorsal horn attenuates neuropathic pain hypersensitivity by increasing mitochondrial fission

Targeted up-regulation of Drp1 in dorsal horn attenuates neuropathic pain hypersensitivity by increasing mitochondrial fission

Mitochondria play an essential role in pathophysiology of both inflammatory and neuropathic pain (NP), but the mechanisms are not yet clear. Dynamin-related protein 1 (Drp1) is broadly expressed in the central nervous system and plays a role in the induction of mitochondrial fission process. Spared...

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Bibliographic Details
Main Authors: Kun-Long Zhang, Shu-Jiao Li, Xue-Yin Pu, Fei-Fei Wu, Hui Liu, Rui-Qing Wang, Bo-Zhi Liu, Ze Li, Kai-Feng Li, Nian-Song Qian, Yan-Ling Yang, Hua Yuan, Ya-Yun Wang
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Redox Biology
Subjects:
Drp1
Mitochondria
SNI
Pain
Spinal dorsal horn
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721003761

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http://www.sciencedirect.com/science/article/pii/S2213231721003761

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