Ionic co-aggregates (ICAs) based oral drug delivery: Solubilization and permeability improvement

Ionic co-aggregates (ICAs) based oral drug delivery: Solubilization and permeability improvement

Due to the overwhelming percentage of poorly water-soluble drugs, pharmaceutical industry is in urgent need of efficient approaches for solubilization and permeability improvement. Salts consisting of lipophilic fatty acid anions and hydrophilic choline cations are found to be surface active and abl...

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Bibliographic Details
Main Authors: Xianzi Zheng, Zhezheng Fang, Weizi Huang, Jianping Qi, Xiaochun Dong, Weili Zhao, Wei Wu, Yi Lu
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Ionic co-aggregates
Molecular dynamics simulation
Oral
Bioavailability
Aggregation-caused quenching
Paclitaxel
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522001824

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http://www.sciencedirect.com/science/article/pii/S2211383522001824

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