Small extracellular vesicles and particles (sEVPs) derived from tumor-free pre-metastatic organs promote breast cancer metastasis and support organotropism

Small extracellular vesicles and particles (sEVPs) derived from tumor-free pre-metastatic organs promote breast cancer metastasis and support organotropism

Abstract Metastatic breast cancer remains largely incurable, partly due to our incomplete understanding of its intricate underlying mechanisms. Notably, intercellular communication mediated by small extracellular vesicles and particles (sEVPs) has emerged as a key feature of metastasis. While tumor-...

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Bibliographic Details
Main Authors: Tasneem Cheytan, Martin Schneider, Roberto Würth, Paul Schwerd-Kleine, Ewgenija Gutjahr, Verena Thewes, Laura L. Michel, Rebecca Weber, Tim Vorberg, Sabrina Lohr, Katja Nitschke, Michelle Neßling, Peter Lichter, Andreas Schneeweiss, Karsten Richter, Dominic Helm, Martin Sprick, Andreas Trumpp
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Molecular Cancer
Subjects:
Small extracellular vesicles and particles (sEVPs)
Breast cancer
Brain metastasis
Lung metastasis
Global proteomics analysis
Dihydrofolate reductase-mediated metastasis
Online Access:https://doi.org/10.1186/s12943-025-02235-8

Internet

https://doi.org/10.1186/s12943-025-02235-8

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