Drosophila noktochor regulates night sleep via a local mushroom body circuit

Summary: We show that a sleep-regulating, Ig-domain protein (NKT) is secreted from Drosophila mushroom body (MB) α′/β′ neurons to act locally on other MB cell types. Pan-neuronal or broad MB expression of membrane-tethered NKT (tNkt) protein reduced sleep, like that of an NKT null mutant, suggesting...

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Bibliographic Details
Main Authors: Isabelle R. Draper, Mary A. Roberts, Matthew Gailloud, F. Rob Jackson
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224003274