Paradoxical impact of two folate receptors, FRα and RFC, in ovarian cancer: effect on cell proliferation, invasion and clinical outcome.

Paradoxical impact of two folate receptors, FRα and RFC, in ovarian cancer: effect on cell proliferation, invasion and clinical outcome.

Despite being an essential vitamin, folate has been implicated to enhance tumor growth, as evidenced by reports on overexpression of folate receptor alpha (FRα) in carcinomas. The role of another folate transporter, reduced folate carrier (RFC), is largely unknown. This study investigated the roles...

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Bibliographic Details
Main Authors: Michelle K Y Siu, Daniel S H Kong, Hoi Yan Chan, Esther S Y Wong, Philip P C Ip, LiLi Jiang, Hextan Y S Ngan, Xiao-Feng Le, Annie N Y Cheung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23144806/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23144806/?tool=EBI

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