Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis

Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis

This study reports on the synthesis and evaluation of novel compounds replacing the nitrogen-containing heterocyclic ring on the chemical backbone structure of cytochrome P450 17α-hydroxylase/12,20-lyase (CYP17A1) inhibitors with a phenyl bearing a sulfur-based substituent. Initial screening reveale...

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Bibliographic Details
Main Authors: Tomasz M. Wróbel, Katyayani Sharma, Iole Mannella, Simonetta Oliaro-Bosso, Patrycja Nieckarz, Therina Du Toit, Clarissa Daniela Voegel, Maria Natalia Rojas Velazquez, Jibira Yakubu, Anna Matveeva, Søren Therkelsen, Flemming Steen Jørgensen, Amit V. Pandey, Agnese C. Pippione, Marco L. Lolli, Donatella Boschi, Fredrik Björkling
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Biomolecules
Subjects:
CYP17A1
AKR1C3
prostate cancer
enzyme inhibition
Online Access:https://www.mdpi.com/2218-273X/13/9/1349

Internet

https://www.mdpi.com/2218-273X/13/9/1349

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