Mutual interaction of neurons and astrocytes derived from iPSCs with APP V717L mutation developed the astrocytic phenotypes of Alzheimer’s disease

Mutual interaction of neurons and astrocytes derived from iPSCs with APP V717L mutation developed the astrocytic phenotypes of Alzheimer’s disease

Abstract Background The development of induced pluripotent stem cells (iPSCs) technology has enabled human cellular disease modeling for inaccessible cell types, such as neural cells in the brain. However, many of the iPSC-derived disease models established to date typically involve only a single ce...

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Bibliographic Details
Main Authors: Sopak Supakul, Rei Murakami, Chisato Oyama, Tomoko Shindo, Yuki Hatakeyama, Maika Itsuno, Hiroko Bannai, Shinsuke Shibata, Sumihiro Maeda, Hideyuki Okano
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Inflammation and Regeneration
Subjects:
Induced pluripotent stem cells (iPSCs)
Neurons
Astrocytes
Co-culture model
Tripartite synapse
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s41232-023-00310-5

Internet

https://doi.org/10.1186/s41232-023-00310-5

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