Determination of Extravasation Effects of Nal-Iri and Trabectedin and Evaluation of Treatment Options for Trabectedin Extravasation in a Preclinical Animal Model

Determination of Extravasation Effects of Nal-Iri and Trabectedin and Evaluation of Treatment Options for Trabectedin Extravasation in a Preclinical Animal Model

Background: Extravasation during chemotherapy administration can lead to dangerous adverse effects ranging from pain to tissue necrosis. Evidence-based data about prevention and treatment of extravasation injuries of some clinically used compounds still remains elusive. This work aimed to investigat...

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Bibliographic Details
Main Authors: Omar Keritam, Viktoria Juhasz, Christian Schöfer, Christiane Thallinger, Marie-Bernadette Aretin, Gernot Schabbauer, Johannes Breuss, Matthias Unseld, Pavel Uhrin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
extravasation
nanoliposomal irinotecan
trabectedin
hyaluronidase
DMSO
tacrolimus
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.875695/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.875695/full

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