Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis

Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis

Abstract Systemic lupus erythematosus (SLE), a severe autoimmune disorder, is characterized by systemic inflammatory response, autoantibody accumulation and damage to organs. The dysregulation of double-negative (DN) T cells is considered as a crucial commander during SLE. Neddylation, a significant...

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Bibliographic Details
Main Authors: Yun Zhang, Lijun Du, Chenxi Wang, Zhangsheng Jiang, Qingchi Duan, Yiping Li, Zhijun Xie, Zhixing He, Yi Sun, Lin Huang, Liwei Lu, Chengping Wen
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01709-9

Internet

https://doi.org/10.1038/s41392-023-01709-9

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