Exogenous IL-25 ameliorates airway neutrophilia via suppressing macrophage M1 polarization and the expression of IL-12 and IL-23 in asthma

Exogenous IL-25 ameliorates airway neutrophilia via suppressing macrophage M1 polarization and the expression of IL-12 and IL-23 in asthma

Abstract Background Severe asthma is associated with substantial mortality and has unmet therapeutic need. A subset of severe asthma is characterized by neutrophilic airway inflammation. Classically activated (or M1) macrophages which express IL-12 and IL-23 are associated with airway neutrophilia i...

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Bibliographic Details
Main Authors: Chenli Chang, Gongqi Chen, Wenliang Wu, Dian Chen, Shengchong Chen, Jiali Gao, Yuchen Feng, Guohua Zhen
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Respiratory Research
Subjects:
Asthma
Airway inflammation
Neutrophilia
Macrophage polarization
IL-12
IL-23
Online Access:https://doi.org/10.1186/s12931-023-02557-5

Internet

https://doi.org/10.1186/s12931-023-02557-5

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