Assessing biological network dynamics: comparing numerical simulations with analytical decomposition of parameter space

Abstract Mathematical modeling of the emergent dynamics of gene regulatory networks (GRN) faces a double challenge of (a) dependence of model dynamics on parameters, and (b) lack of reliable experimentally determined parameters. In this paper we compare two complementary approaches for describing GR...

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Bibliographic Details
Main Authors: Kishore Hari, William Duncan, Mohammed Adil Ibrahim, Mohit Kumar Jolly, Breschine Cummins, Tomas Gedeon
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-023-00289-2