Complement C1q Interacts With LRP1 Clusters II and IV Through a Site Close but Different From the Binding Site of Its C1r and C1s-Associated Proteases

Complement C1q Interacts With LRP1 Clusters II and IV Through a Site Close but Different From the Binding Site of Its C1r and C1s-Associated Proteases

LRP1 is a large endocytic modular receptor that plays a crucial role in the scavenging of apoptotic material through binding to pattern-recognition molecules. It is a membrane anchored receptor of the LDL receptor family with 4 extracellular clusters of ligand binding modules called cysteine rich co...

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Bibliographic Details
Main Authors: Guillaume Fouët, Evelyne Gout, Catherine Wicker-Planquart, Isabelle Bally, Camilla De Nardis, Stéphane Dedieu, Anne Chouquet, Christine Gaboriaud, Nicole M. Thielens, Jean-Philippe Kleman, Véronique Rossi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
complement C1q
scavenger receptor
LRP1
CD91
interaction
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.583754/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.583754/full

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