Phenotypic switching induced by damaged matrix is associated with DNA methyltransferase 3A (DNMT3A) activity and nuclear localization in smooth muscle cells (SMC).

Phenotypic switching induced by damaged matrix is associated with DNA methyltransferase 3A (DNMT3A) activity and nuclear localization in smooth muscle cells (SMC).

Extracellular matrix changes are often crucial inciting events for fibroproliferative disease. Epigenetic changes, specifically DNA methylation, are critical factors underlying differentiated phenotypes. We examined the dependency of matrix-induced fibroproliferation and SMC phenotype on DNA methylt...

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Bibliographic Details
Main Authors: Jia-Xin Jiang, Karen J Aitken, Chris Sotiropoulos, Tyler Kirwan, Trupti Panchal, Nicole Zhang, Shuye Pu, Shoshana Wodak, Cornelia Tolg, Darius J Bägli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3735580?pdf=render

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http://europepmc.org/articles/PMC3735580?pdf=render

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