miR-221/222 sponge abrogates tamoxifen resistance in ER-positive breast cancer cells through restoring the expression of ERα

miR-221/222 sponge abrogates tamoxifen resistance in ER-positive breast cancer cells through restoring the expression of ERα

Abstract Tamoxifen resistance (TamR) prevents ER-positive breast cancer patients from benefitting from endocrine therapy, and miR-221 or miR-222 plays vital roles in inducing TamR. In this study, we designed synthetic sponges to reverse TamR by targeting these two miRs. First, we established a tamox...

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Bibliographic Details
Main Authors: Yan Xiu Ouyang, Jun Feng, Zun Wang, Guo Jun Zhang, Min Chen
Format: Article
Language:English
Published: Springer 2021-06-01
Series:Molecular Biomedicine
Subjects:
Breast cancer
Tamoxifen resistance
Sponge
miR-221/222
hTERT promoter
Online Access:https://doi.org/10.1186/s43556-021-00045-0

Internet

https://doi.org/10.1186/s43556-021-00045-0

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