Computational analysis of missense variant CYP4F2*3 (V433M) in association with human CYP4F2 dysfunction: a functional and structural impact

Computational analysis of missense variant CYP4F2*3 (V433M) in association with human CYP4F2 dysfunction: a functional and structural impact

Abstract Background Cytochrome P450 4F2 (CYP4F2) enzyme is a member of the CYP4 family responsible for the metabolism of fatty acids, therapeutic drugs, and signaling molecules such as arachidonic acid, tocopherols, and vitamin K. Several reports have demonstrated that the missense variant CYP4F2*3...

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Bibliographic Details
Main Authors: Mahvash Farajzadeh-Dehkordi, Ladan Mafakher, Fatemeh Samiee-Rad, Babak Rahmani
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Molecular and Cell Biology
Subjects:
Damaging variant
CYP4F2*3
V433M variation
Warfarin
Vitamin K1
In silico
Online Access:https://doi.org/10.1186/s12860-023-00479-0

Internet

https://doi.org/10.1186/s12860-023-00479-0

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