The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell Line

The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell Line

The involvement of sirtuins (SIRTs) in modulating metabolic and stress response pathways is attracting growing scientific interest. Some SIRT family members are located in mitochondria, dynamic organelles that perform several crucial functions essential for eukaryotic life. Mitochondrial dysfunction...

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Bibliographic Details
Main Authors: Vincenzo Carafa, Rosita Russo, Laura Della Torre, Francesca Cuomo, Carmela Dell'Aversana, Federica Sarno, Giulia Sgueglia, Marzia Di Donato, Dante Rotili, Antonello Mai, Angela Nebbioso, Gilda Cobellis, Angela Chambery, Lucia Altucci
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
sirtuins
epigenetic
mitochondria
cancer
leukemia
energy production
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00820/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00820/full

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