The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell Line
The involvement of sirtuins (SIRTs) in modulating metabolic and stress response pathways is attracting growing scientific interest. Some SIRT family members are located in mitochondria, dynamic organelles that perform several crucial functions essential for eukaryotic life. Mitochondrial dysfunction...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.00820/full |
| _version_ | 1828888964998627328 |
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| author | Vincenzo Carafa Rosita Russo Laura Della Torre Francesca Cuomo Carmela Dell'Aversana Carmela Dell'Aversana Federica Sarno Giulia Sgueglia Marzia Di Donato Dante Rotili Antonello Mai Angela Nebbioso Gilda Cobellis Angela Chambery Lucia Altucci |
| author_facet | Vincenzo Carafa Rosita Russo Laura Della Torre Francesca Cuomo Carmela Dell'Aversana Carmela Dell'Aversana Federica Sarno Giulia Sgueglia Marzia Di Donato Dante Rotili Antonello Mai Angela Nebbioso Gilda Cobellis Angela Chambery Lucia Altucci |
| author_sort | Vincenzo Carafa |
| collection | DOAJ |
| description | The involvement of sirtuins (SIRTs) in modulating metabolic and stress response pathways is attracting growing scientific interest. Some SIRT family members are located in mitochondria, dynamic organelles that perform several crucial functions essential for eukaryotic life. Mitochondrial dysfunction has emerged as having a key role in a number of human diseases, including cancer. Here, we investigated mitochondrial damage resulting from treatment with a recently characterized pan-SIRT inhibitor, MC2494. MC2494 was able to block mitochondrial biogenesis and function in terms of ATP synthesis and energy metabolism, suggesting that it might orchestrate cell response to metabolic stress and thereby interfere with cancer promotion and progression. Targeting mitochondrial function could thus be considered a potential anticancer strategy for use in clinical therapy. |
| first_indexed | 2024-12-13T12:32:54Z |
| format | Article |
| id | doaj.art-40d77db6f02548b7907a7c687fa28f32 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-13T12:32:54Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-40d77db6f02548b7907a7c687fa28f322022-12-21T23:45:58ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-05-011010.3389/fonc.2020.00820534426The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell LineVincenzo Carafa0Rosita Russo1Laura Della Torre2Francesca Cuomo3Carmela Dell'Aversana4Carmela Dell'Aversana5Federica Sarno6Giulia Sgueglia7Marzia Di Donato8Dante Rotili9Antonello Mai10Angela Nebbioso11Gilda Cobellis12Angela Chambery13Lucia Altucci14Dipartimento di Medicina di Precisione, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyDipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche, Università degli Studi della Campania “Luigi Vanvitelli”, Caserta, ItalyDipartimento di Medicina di Precisione, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyDipartimento di Medicina di Precisione, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyDipartimento di Medicina di Precisione, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyInstitute Experimental Endocrinology and Oncology “Gaetano Salvatore” (IEOS)- National Research Council (CNR), Naples, ItalyDipartimento di Medicina di Precisione, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyDipartimento di Medicina di Precisione, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyDipartimento di Medicina di Precisione, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyDipartimento di Chimica e Tecnologie del Farmaco, “Sapienza” Università di Roma, Rome, ItalyDipartimento di Chimica e Tecnologie del Farmaco, “Sapienza” Università di Roma, Rome, ItalyDipartimento di Medicina di Precisione, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyDipartimento di Medicina di Precisione, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyDipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche, Università degli Studi della Campania “Luigi Vanvitelli”, Caserta, ItalyDipartimento di Medicina di Precisione, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyThe involvement of sirtuins (SIRTs) in modulating metabolic and stress response pathways is attracting growing scientific interest. Some SIRT family members are located in mitochondria, dynamic organelles that perform several crucial functions essential for eukaryotic life. Mitochondrial dysfunction has emerged as having a key role in a number of human diseases, including cancer. Here, we investigated mitochondrial damage resulting from treatment with a recently characterized pan-SIRT inhibitor, MC2494. MC2494 was able to block mitochondrial biogenesis and function in terms of ATP synthesis and energy metabolism, suggesting that it might orchestrate cell response to metabolic stress and thereby interfere with cancer promotion and progression. Targeting mitochondrial function could thus be considered a potential anticancer strategy for use in clinical therapy.https://www.frontiersin.org/article/10.3389/fonc.2020.00820/fullsirtuinsepigeneticmitochondriacancerleukemiaenergy production |
| spellingShingle | Vincenzo Carafa Rosita Russo Laura Della Torre Francesca Cuomo Carmela Dell'Aversana Carmela Dell'Aversana Federica Sarno Giulia Sgueglia Marzia Di Donato Dante Rotili Antonello Mai Angela Nebbioso Gilda Cobellis Angela Chambery Lucia Altucci The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell Line Frontiers in Oncology sirtuins epigenetic mitochondria cancer leukemia energy production |
| title | The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell Line |
| title_full | The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell Line |
| title_fullStr | The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell Line |
| title_full_unstemmed | The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell Line |
| title_short | The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell Line |
| title_sort | pan sirtuin inhibitor mc2494 regulates mitochondrial function in a leukemia cell line |
| topic | sirtuins epigenetic mitochondria cancer leukemia energy production |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.00820/full |
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