Tauroursodeoxycholic acid (TUDCA) improves intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets

Tauroursodeoxycholic acid (TUDCA) improves intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets

Abstract Background Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, is the main medicinal component of bear bile and is commonly used to treat a variety of hepatobiliary diseases. Meanwhile, TUDCA has been shown to modulate the intestinal barrier function and alleviate DSS-induced coliti...

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Bibliographic Details
Main Authors: Min Song, Fenglin Zhang, Yiming Fu, Xin Yi, Shengchun Feng, Zhichang Liu, Dun Deng, Qiang Yang, Miao Yu, Canjun Zhu, Xiaotong Zhu, Lina Wang, Ping Gao, Gang Shu, Xianyong Ma, Qingyan Jiang, Songbo Wang
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Animal Science and Biotechnology
Subjects:
Gut bacteria
Intestinal barrier function
Serum metabolites
Tauroursodeoxycholic acid (TUDCA)
TGR5-MLCK pathway
Weaned piglets
Online Access:https://doi.org/10.1186/s40104-022-00713-3

Internet

https://doi.org/10.1186/s40104-022-00713-3

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