DNA-Damage-Induced Type I Interferon Promotes Senescence and Inhibits Stem Cell Function

DNA-Damage-Induced Type I Interferon Promotes Senescence and Inhibits Stem Cell Function

Expression of type I interferons (IFNs) can be induced by DNA-damaging agents, but the mechanisms and significance of this regulation are not completely understood. We found that the transcription factor IRF3, activated in an ATM-IKKα/β-dependent manner, stimulates cell-autonomous IFN-β expression i...

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Bibliographic Details
Main Authors: Qiujing Yu, Yuliya V. Katlinskaya, Christopher J. Carbone, Bin Zhao, Kanstantsin V. Katlinski, Hui Zheng, Manti Guha, Ning Li, Qijun Chen, Ting Yang, Christopher J. Lengner, Roger A. Greenberg, F. Brad Johnson, Serge Y. Fuchs
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715003605

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http://www.sciencedirect.com/science/article/pii/S2211124715003605

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