Whole-exome sequencing and an iPSC-derived cardiomyocyte model provides a powerful platform for gene discovery in left ventricular hypertrophy

Whole-exome sequencing and an iPSC-derived cardiomyocyte model provides a powerful platform for gene discovery in left ventricular hypertrophy

Rationale: Left ventricular hypertrophy (LVH) is a heritable predictor of cardiovascular disease, particularly in blacks. Objective: Determine the feasibility of combining evidence from two distinct but complimentary experimental approaches to identify novel genetic predictors of increased LV mass ....

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Bibliographic Details
Main Authors: Degui eZhi, Ryan eIrvin, Charles eGu, Alexander eStoddard, Rachel eLorier, Andrea eMatter, D C Rao, Vinodh eSrinivasasainagendra, Hemant K Tiwari, Amy eTurner, Ulrich eBroeckel, Donna K Arnett
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-05-01
Series:Frontiers in Genetics
Subjects:
Exome
Hypertrophy
cardiomyocyte
left ventricular mass
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00092/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00092/full

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