Inhibition Studies on Human and Mycobacterial Carbonic Anhydrases with <i>N</i>-((4-Sulfamoylphenyl)carbamothioyl) Amides

Inhibition Studies on Human and Mycobacterial Carbonic Anhydrases with <i>N</i>-((4-Sulfamoylphenyl)carbamothioyl) Amides

A library of structurally diverse <i>N</i>-((4-sulfamoylphenyl)carbamothioyl) amides was synthesized by selective acylation of easily accessible 4-thioureidobenzenesulfonamide with various aliphatic, benzylic, vinylic and aromatic acyl chlorides under mild conditions. Inhibition of three...

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Bibliographic Details
Main Authors: Morteza Abdoli, Alessandro Bonardi, Niccolò Paoletti, Ashok Aspatwar, Seppo Parkkila, Paola Gratteri, Claudiu T. Supuran, Raivis Žalubovskis
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Molecules
Subjects:
carbonic anhydrase
inhibitors
sulfonamides
bacterial enzymes
<i>Mycobacterium tuberculosis</i>
in silico studies
Online Access:https://www.mdpi.com/1420-3049/28/10/4020

Internet

https://www.mdpi.com/1420-3049/28/10/4020

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