Tissue-specific and tissue-agnostic effects of genome sequence variation modulating blood pressure

Summary: Genome-wide association studies (GWASs) have identified numerous variants associated with polygenic traits and diseases. However, with few exceptions, a mechanistic understanding of which variants affect which genes in which tissues to modulate trait variation is lacking. Here, we present g...

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Bibliographic Details
Main Authors: Dongwon Lee, Seong Kyu Han, Or Yaacov, Hanna Berk-Rauch, Prabhu Mathiyalagan, Santhi K. Ganesh, Aravinda Chakravarti
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723013633