SiNiSan Ameliorates the Depression-Like Behavior of Rats That Experienced Maternal Separation Through 5-HT1A Receptor/CREB/BDNF Pathway

SiNiSan Ameliorates the Depression-Like Behavior of Rats That Experienced Maternal Separation Through 5-HT1A Receptor/CREB/BDNF Pathway

Background: Early adverse life stress is an important dangerous factor in the development of psychiatric disorders, particularly depression. Available clinical antidepressant agents, such as fluoxetine, [a selective serotonin reuptake inhibitor (SSRI)], are unsatisfactory because of their side effec...

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Bibliographic Details
Main Authors: Kerun Cao, Chongkun Shen, Yumei Yuan, Shasha Bai, Lei Yang, Lili Guo, Rong Zhang, Yafei Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Psychiatry
Subjects:
SiNiSan
early life stress
depression
brain-derived neurotrophic factor
serotonin 1A receptor
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2019.00160/full

Internet

https://www.frontiersin.org/article/10.3389/fpsyt.2019.00160/full

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