Biochemical and transcriptomic evaluation of a 3D lung organoid platform for pre-clinical testing of active substances targeting senescence

Biochemical and transcriptomic evaluation of a 3D lung organoid platform for pre-clinical testing of active substances targeting senescence

Abstract Chronic lung diseases such as chronic obstructive pulmonary disease and cystic fibrosis are incurable. Epithelial senescence, a state of dysfunctional cell cycle arrest, contributes to the progression of such diseases. Therefore, lung epithelial cells are a valuable target for therapeutic i...

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Bibliographic Details
Main Authors: Michelle Brand, Felix Ritzmann, Kathrin Kattler, Deivydas Milasius, Yiwen Yao, Christian Herr, Susanne H. Kirsch, Rolf Müller, Daniela Yildiz, Robert Bals, Christoph Beisswenger
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Respiratory Research
Subjects:
Lung diseases
Organoid
Senescence
Toxicity
Inflammation
Preclinical studies
Online Access:https://doi.org/10.1186/s12931-023-02636-7

Internet

https://doi.org/10.1186/s12931-023-02636-7

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