Strain-specific differences in the development of bone loss and incidence of osteonecrosis following glucocorticoid treatment in two different mouse strains

Objective: Glucocorticoids (GCs) are commonly prescribed as treatment for chronic inflammatory diseases. Prolonged use of GCs is a common cause of atraumatic osteonecrosis (ON) and secondary osteoporosis. Currently, there is no effective treatment for this disease; therefore, a reliable animal model...

Full description

Bibliographic Details
Main Authors: Kie Shidara, Geetha Mohan, Yan-An Evan Lay, Karl J. Jepsen, Wei Yao, Nancy E. Lane
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Journal of Orthopaedic Translation
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X18300512