Crosstalk Between Autophagy and the cGAS–STING Signaling Pathway in Type I Interferon Production

Crosstalk Between Autophagy and the cGAS–STING Signaling Pathway in Type I Interferon Production

Innate immunity is the front-line defense against infectious microorganisms, including viruses and bacteria. Type I interferons are pleiotropic cytokines that perform antiviral, antiproliferative, and immunomodulatory functions in cells. The cGAS–STING pathway, comprising the main DNA sensor cyclic...

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Bibliographic Details
Main Authors: Kunli Zhang, Sutian Wang, Hongchao Gou, Jianfeng Zhang, Chunling Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
autophagy
CGAS
STING
type I IFNs production
signalling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.748485/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.748485/full

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