Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia

Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia

Postzygotic mutations are acquired in normal tissues throughout an individual’s lifetime and hold clues for identifying mutagenic factors. Here, we investigated postzygotic mutation spectra of healthy individuals using optimized ultra-deep exome sequencing of the time-series samples from the same vo...

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Bibliographic Details
Main Authors: Yaqiang Hong, Dake Zhang, Xiangtian Zhou, Aili Chen, Amir Abliz, Jian Bai, Liang Wang, Qingtao Hu, Kenan Gong, Xiaonan Guan, Mengfei Liu, Xinchang Zheng, Shujuan Lai, Hongzhu Qu, Fuxin Zhao, Shuang Hao, Zhen Wu, Hong Cai, Shaoyan Hu, Yue Ma, Junting Zhang, Yang Ke, Qian-Fei Wang, Wei Chen, Changqing Zeng
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Genomics, Proteomics & Bioinformatics
Subjects:
Postzygotic mutation
Mutational signature
Healthy individual
Embryonic development
Hypoxia
Online Access:http://www.sciencedirect.com/science/article/pii/S1672022921002096

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http://www.sciencedirect.com/science/article/pii/S1672022921002096

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