Superior protection in a relapsing Plasmodium cynomolgi rhesus macaque model by a chemoprophylaxis with sporozoite immunization regimen with atovaquone-proguanil followed by primaquine

Superior protection in a relapsing Plasmodium cynomolgi rhesus macaque model by a chemoprophylaxis with sporozoite immunization regimen with atovaquone-proguanil followed by primaquine

Abstract Background To gain a deeper understanding of protective immunity against relapsing malaria, this study examined sporozoite-specific T cell responses induced by a chemoprophylaxis with sporozoite (CPS) immunization in a relapsing Plasmodium cynomolgi rhesus macaque model. Methods The animals...

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Bibliographic Details
Main Authors: Kosol Yongvanitchit, Utaiwan Kum-Arb, Amporn Limsalakpetch, Rawiwan Im-Erbsin, Ratawan Ubalee, Michele D. Spring, Brian A. Vesely, Norman Waters, Sathit Pichyangkul
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Malaria Journal
Subjects:
Relapsing Plasmodium cynomolgi rhesus macaque model
Chemoprophylaxis with sporozoite immunization
Atovaquone-proguanil
Sporozoite-specific T cell responses
Online Access:https://doi.org/10.1186/s12936-024-04933-y

Internet

https://doi.org/10.1186/s12936-024-04933-y

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