Development and application of the physiologically-based toxicokinetic (PBTK) model for ochratoxin A (OTA) in rats and humans

Development and application of the physiologically-based toxicokinetic (PBTK) model for ochratoxin A (OTA) in rats and humans

Ochratoxin A (OTA) is a common fungal toxin frequently detected in food and human plasma samples. Currently, the physiologically based toxicokinetic (PBTK) model plays an active role in dose translation and can improve and enhance the risk assessment of toxins. In this study, the PBTK model of OTA i...

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Bibliographic Details
Main Authors: Bu-Da Su, Xiao-Meng Li, Zhi-Wei Huang, Yue Wang, Jia Shao, Yan-Yan Xu, Le-Xin Shu, Yu-Bo Li
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Ochratoxin A
human model
inter-specific extrapolation
dose translation
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324003531

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http://www.sciencedirect.com/science/article/pii/S0147651324003531

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