Activation of α7nAChR Protects Against Gastric Inflammation and Dysmotility in Parkinson’s Disease Rats

Activation of α7nAChR Protects Against Gastric Inflammation and Dysmotility in Parkinson’s Disease Rats

The cholinergic anti-inflammatory pathway (CAIP) has been proposed to regulate gastrointestinal inflammation via acetylcholine released from the vagus nerve activating α7 nicotinic receptor (α7nAChR) on macrophages. Parkinson’s disease (PD) patients and PD rats with substantia nigra (SN) lesions exh...

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Bibliographic Details
Main Authors: Li Zhou, Li-Fei Zheng, Xiao-Li Zhang, Zhi-Yong Wang, Yuan-Sheng Yao, Xiao-Lin Xiu, Chen-Zhe Liu, Yue Zhang, Xiao-Yan Feng, Jin-Xia Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Pharmacology
Subjects:
α7nAChR
6-hydroxydopamine
gastric inflammation
macrophage
Parkinson’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.793374/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.793374/full

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