Impaired exercise performance and skeletal muscle mitochondrial function in rats with secondary carnitine deficiency

Impaired exercise performance and skeletal muscle mitochondrial function in rats with secondary carnitine deficiency

Purpose: The effects of carnitine depletion upon exercise performance and skeletal muscle mitochondrial function remain largely unexplored. We therefore investigated the effect of N-trimethyl-hydrazine-3-propionate (THP), a carnitine analogue inhibiting carnitine biosynthesis and renal carnitine rea...

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Bibliographic Details
Main Authors: Jamal BOUITBIR, Patrizia HAEGLER, François SINGH, Lorenz JOERIN, Andrea FELSER, Urs DUTHALER, Stephan KRAEHENBUEHL
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Physiology
Subjects:
Mitochondria
Reactive Oxygen Species
skeletal muscle
Exhaustive exercise
carnitine deficiency
N-trimethyl-hydrazine-3-propionate
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00345/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00345/full

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