Mendelian randomization of circulating proteome identifies actionable targets in heart failure

Mendelian randomization of circulating proteome identifies actionable targets in heart failure

Abstract Background Heart failure (HF) is a prevalent cause of mortality and morbidity. The molecular drivers of HF are still largely unknown. Results We aimed to identify circulating proteins causally associated with HF by leveraging genome-wide genetic association data for HF including 47,309 case...

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Bibliographic Details
Main Authors: Louis-Hippolyte Minvielle Moncla, Samuel Mathieu, Mame Sokhna Sylla, Yohan Bossé, Sébastien Thériault, Benoit J. Arsenault, Patrick Mathieu
Format: Article
Language:English
Published: BMC 2022-08-01
Series:BMC Genomics
Subjects:
Heart failure
Mendelian randomization
Blood protein
Network
Pathway
Druggable genome
Online Access:https://doi.org/10.1186/s12864-022-08811-2

Internet

https://doi.org/10.1186/s12864-022-08811-2

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