A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis

A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis

mir-17-92, a potent polycistronic oncomir, encodes six mature miRNAs with complex modes of interactions. In the Eμ-myc Burkitt’s lymphoma model, mir-17-92 exhibits potent oncogenic activity by repressing c-Myc-induced apoptosis, primarily through its miR-19 components. Surprisingly, mir-17-92 also e...

Full description

Bibliographic Details
Main Authors: Virginie Olive, Erich Sabio, Margaux J Bennett, Caitlin S De Jong, Anne Biton, James C McGann, Samantha K Greaney, Nicole M Sodir, Alicia Y Zhou, Asha Balakrishnan, Mona Foth, Micah A Luftig, Andrei Goga, Terence P Speed, Zhenyu Xuan, Gerard I Evan, Ying Wan, Alex C Minella, Lin He
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-10-01
Series:eLife
Subjects:
microRNA
c-Myc
Eμ-myc lymphoma
apoptosis
p53
Online Access:https://elifesciences.org/articles/00822

Internet

https://elifesciences.org/articles/00822

Similar Items